Recruiting

Testing small implants that deliver cancer medicine directly to the prostate

Plain-English translation of NCT06257693 on ClinicalTrials.gov ↗ · Source last updated August 2026 · Translation generated August 2026 · How we translate trials

Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.

What is this trial?

This study is testing a new treatment approach called Enolen—tiny implants that deliver a cancer-fighting medicine called directly into prostate tissue. Researchers want to learn whether these implants are safe, how well patients tolerate them, and what happens to the prostate tissue over time. You would receive the implants and then have your prostate surgically removed 6 weeks to 12 months later, depending on which group you're assigned to.

Currently, men with prostate cancer receive cancer-fighting drugs by mouth or injection, which affects the whole body. This trial explores whether delivering the medicine directly into the prostate itself—using tiny implants—could be safer and more effective.

Do you qualify?

You likely qualify if…

you are at least 21 years old
you have been diagnosed with prostate adenocarcinoma confirmed by biopsy
you are already planning to have your prostate surgically removed
you have at least one prostate tumor visible on MRI that is 0.5 cm or larger
your cancer meets specific grade criteria (Gleason score 3+4 or higher for some groups, 3+3 with high-risk features for others)
you are willing to have MRI scans and are physically able to undergo MRI safely

You likely don't qualify if…

you have had previous surgery or radiation treatment for prostate cancer
you are currently taking hormone therapy for prostate cancer, or stopped it less than 3 months ago
you have had prior minimally invasive prostate procedures
you have metal implants or medical devices that would interfere with MRI imaging
you have prostate cancer that has spread to other parts of your body

What participation looks like

You would have an MRI scan of your prostate, then receive the small implants through a needle procedure. Depending on your assigned group, you would have your prostate surgically removed between 6 weeks and 12 months after receiving the implants. You would then be followed with office visits, blood tests, and quality-of-life surveys for 6–12 weeks after surgery. Some participants may be asked to continue MRI imaging and biopsies for up to 24 months if they choose to delay surgery.

AI-generated summary from trial data · Aug 19, 2026 · Not medical advice

Trial locations(10 sites)

United States

Urology Associates of Central California, Fresno, California

University of California San Francisco Helen Diller Family Comprehensive Cancer Center, San Francisco, California

Northwestern University, Chicago, Illinois

Mary Bird Cancer Center, Metairie, Louisiana

Johns Hopkins University School of Medicine, Baltimore, Maryland