Plain-English translation of NCT06263153 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing a combination of two medications — and — given before surgery to remove the bladder in patients with muscle-invasive bladder cancer. You would take as a daily pill and receive as an infusion once a month for up to three months, then have surgery. The goal is to see if this medication combination can shrink the cancer before surgery and help patients who cannot tolerate the standard chemotherapy treatment.
Many patients with muscle-invasive bladder cancer are too weak or have kidney or heart problems that make standard chemotherapy too risky. This trial exists to find a safer option for these patients that might still help shrink their cancer before surgery.
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You would visit the clinic once per month for three months to take the medication and receive infusions. During this time, you would take a daily pill at home and come in for blood tests and imaging scans (CT and MRI). After three months of treatment, you would have surgery to remove your bladder as planned. After surgery, you would have follow-up visits at 30 days and then every three months for two years to monitor your health.
AI-generated summary from trial data · Jun 10, 2026 · Not medical advice
United States