Plain-English translation of NCT06268626 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Researchers are testing whether simple vaginal swabs and health questionnaires can help detect uterine cancer and pre-cancerous changes earlier in women with abnormal uterine bleeding. Right now, doctors use surgical biopsies to check for cancer, which is invasive. This study wants to see if non-invasive tests—like swabs that measure DNA patterns and vaginal bacteria—can predict cancer risk before symptoms get worse, so women can get help sooner.
Abnormal uterine bleeding sends many women for invasive biopsies, but most don't have cancer. This research aims to create a simpler, earlier detection method so doctors can identify which women truly need urgent care and which can be monitored more safely at home.
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If you join, you'll first complete health questionnaires and have a standard endometrial biopsy as planned by your doctor. Then, if selected, you'll self-collect a vaginal swab and pH sample at home and mail them in for testing. If your biopsy shows pre-cancerous changes and you keep your uterus, you may be invited to continue monitoring for 6 additional months, collecting samples every few weeks to track how things change over time.
AI-generated summary from trial data · Jun 7, 2026 · Not medical advice
Canada
Sponsor
University of British Columbia
Collaborators
Canadian Institutes of Health Research (CIHR)
Enrollment target
~1,000 participants
Started
October 2024
Primary completion
January 2027
Age range
40 Years and older
Sex
Female only
Last updated on clinicaltrials.gov in April 2026.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Aline Talhouk, PhD
University of British Columbia
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.