Recruiting

Testing a new vaccine to prevent tuberculosis in young adults

Plain-English translation of NCT06272812 on ClinicalTrials.gov ↗ · Source last updated March 2026 · Translation generated June 2026 · How we translate trials

Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.

What is this trial?

This trial is testing a new tuberculosis vaccine called to see if it can protect people from developing TB disease. The study will enroll 5,500 healthy teenagers and adults living in regions where tuberculosis is prevalent. Half of the participants will receive the new vaccine, and half will receive a placebo (a dummy injection with no medicine), so researchers can fairly measure how well the medication works.

Tuberculosis remains a serious global health threat, and current prevention tools are not always effective, especially in people who have already been exposed to TB. This trial exists to determine whether this new treatment can provide better protection against developing active TB disease in vulnerable populations.

Do you qualify?

You likely qualify if…

you are between 14 and 45 years old
you are HIV-negative
you are in good general health
you do not have active tuberculosis or a history of TB disease
you have not lived closely with someone who has TB in the past 6 months
you are willing to use contraception (if you are a woman of reproductive age or a man with a female partner) for at least 2 weeks to 2 months after vaccination

You likely don't qualify if…

you have a fever or acute illness on the day of vaccination
you have active tuberculosis disease or symptoms of TB
you have previously been treated for TB disease
you have received TB preventive therapy in the past
you are pregnant or breastfeeding

What participation looks like

You will receive one injection of either the new vaccine or placebo on the first day of the study. After that, you will be followed regularly for several years through clinic visits and check-ins to see if you develop tuberculosis. You will learn to recognize TB symptoms and report them right away, and researchers will perform tests if needed to confirm whether you have developed TB. You will also have blood tests for HIV once a year and be asked about any side effects you experience.

AI-generated summary from trial data · Jun 6, 2026 · Not medical advice

Trial locations(16 sites)

Kenya

Victoria Biomedical Research Institute, Kisumu

Kenya Medical Research Institute, Nairobi

South Africa

JOSHA Research, Bloemfontein

South African Tuberculosis Vaccine Initiative, Cape Town

TASK Applied Science Pty Ltd. TASK Delft, Cape Town