Plain-English translation of NCT06272812 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing a new tuberculosis vaccine called to see if it can protect people from developing TB disease. Researchers will give some participants the vaccine and others a placebo (a harmless injection with no medicine) to compare how well it works. The study involves 5,500 healthy teenagers and adults in regions where tuberculosis is widespread.
Tuberculosis remains a serious global health threat, and current vaccines don't always provide strong protection in adults. This trial is exploring whether this medication might offer better protection for people at risk of TB, especially those living in areas where the disease is common.
You will receive one injection of either the new vaccine or placebo on day one. After that, you'll return for regular check-ups over an extended follow-up period to see whether you develop TB disease—researchers will teach you to recognize TB symptoms and ask you to report them immediately. You'll also have blood tests for HIV once per year and may be selected for additional safety monitoring that includes blood work and tracking of any side effects.
AI-generated summary from trial data · Sep 20, 2026 · Not medical advice
Kenya
South Africa