Plain-English translation of NCT06273527 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.
This study is testing a computer-based brain training program designed to improve your ability to control unwanted thoughts and memories. The program is called COGENT, and it works by having you practice a working memory task on a computer that gradually becomes more challenging. Researchers believe that this targeted brain training may help reduce the difficult, repetitive thoughts that often come with anxiety, depression, or trauma.
Millions of Americans struggle with anxiety, depression, and trauma-related disorders, and one of the biggest challenges is that their brains have difficulty controlling repetitive negative thoughts. Current treatments don't specifically target the brain's executive functioning—the system that helps you manage and push aside unwanted thoughts—so this new treatment aims to fill that gap by training these cognitive abilities directly.
You likely qualify if…
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If you join this study, you will be randomly assigned to either receive the COGENT brain training program or a comparison computer task that doesn't provide active training. You'll complete your assigned computer task multiple times over the study period. The researchers will also measure your progress using thinking and memory tests, and may ask you to complete brain imaging scans (MRI) to see how your brain changes. The study involves visits to the research clinic where they'll assess your symptoms and cognitive abilities before, during, and after the training program.
AI-generated summary from trial data · Jun 5, 2026 · Not medical advice
United States