Plain-English translation of NCT06274528 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Alzheimer Disease research guide →Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
Researchers are testing whether lemborexant, a medication that helps people sleep better, can slow early signs of Alzheimer's disease in older adults who are cognitively normal but have amyloid buildup in their brains. The theory is that better sleep over 6 months may help reduce harmful proteins linked to Alzheimer's disease. This is an early-stage trial to see if this approach is safe and actually works.
Sleep problems are linked to Alzheimer's disease, and better sleep might help clear harmful proteins from the brain before memory loss begins. This medication is designed to deepen sleep, and researchers want to know if it can slow the earliest biological changes of the disease.
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You will take a capsule by mouth once each night, about 30 minutes before bed, for 6 months. You may receive the medication at one of two doses, or a placebo (inactive pill) — you won't know which. You'll have regular study visits to check your safety, and you may have blood drawn and a spinal fluid sample taken (via a lumbar puncture) to measure changes in Alzheimer's-related proteins.
AI-generated summary from trial data · Jul 18, 2026 · Not medical advice
United States
Phase
Testing effectiveness
Sponsor
University of Minnesota
Collaborators
National Institutes of Health (NIH), Eisai Inc.
Enrollment target
~201 participants
Started
March 2024
Primary completion
March 2030
Age range
65 Years and older
Last updated on clinicaltrials.gov in July 2026.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Chloe Meehan, MA
Washington University School of Medicine
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.