Plain-English translation of NCT06274567 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Bipolar Disorder research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing a treatment called accelerated intermittent theta burst stimulation (aiTBS)—a rapid form of magnetic brain stimulation—to see if it can help people with bipolar disorder better manage their emotions during depressive episodes. The study will use brain imaging and computer tasks to measure whether this treatment strengthens the brain's emotion-control systems. Half of the participants will receive active stimulation and half will receive a placebo (sham) stimulation, so researchers can fairly compare the results.
People with bipolar disorder often struggle with depression and difficulty controlling their emotions, which can last a long time and significantly affect their daily lives. This trial exists to explore whether this newer form of brain stimulation could offer a more effective way to help these patients regulate their emotions and improve their mood.
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You will start with baseline visits where you'll complete questionnaires and computer tasks to measure your emotion regulation, followed by a brain imaging scan (MRI). Then you'll be randomly assigned to receive either active or sham brain stimulation sessions—six high-intensity sessions per day over 4 days (24 sessions total). Finally, you'll return for a follow-up brain scan 3 days after your last stimulation session to measure any changes in your brain activity and emotional control.
AI-generated summary from trial data · Jun 23, 2026 · Not medical advice
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