Plain-English translation of NCT06276686 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.
This is an early-stage study testing whether adding supervised exercise to standard cancer treatment can help people with locally advanced rectal cancer. You would do aerobic exercise (like cycling) and resistance training over 11 weeks — starting 2 weeks before your chemotherapy and radiation begin, continuing through treatment, and for 4 weeks after. The goal is to see if exercise helps make the treatment work better and improves how you feel.
Studies suggest that staying physically active during cancer treatment may help improve how well the treatment works and reduce side effects, but we need to test this carefully in people receiving this specific type of cancer care.
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You would come to Castle Hill Hospital for a baseline visit to measure your fitness and collect health information. Then, over 11 weeks, you would do supervised cycling exercise twice a week at the hospital gym under a physiotherapist's guidance, plus home-based resistance training twice a week following provided instructions. You would continue this through your regular chemotherapy and radiation treatment and for 4 weeks afterward. The study team would track your progress and collect information about how you're doing throughout the process.
AI-generated summary from trial data · Aug 31, 2026 · Not medical advice
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