Plain-English translation of NCT06277362 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This trial is studying a procedure called arterial-venous reversal flow for patients with critical limb-threatening ischemia — a serious condition where blood flow to the lower leg is severely blocked — who cannot benefit from standard treatments. The procedure uses a healthy vein to carry oxygen-rich blood directly to the foot, bypassing the damaged arteries. Researchers want to see if this approach can help save limbs and prevent amputation in patients who have run out of other options.
About 10-15% of patients with critical circulation problems in their legs cannot benefit from standard treatments like angioplasty or bypass surgery, leaving them at high risk of losing their limb. This trial exists to find out whether using veins to restore blood flow might be a lifesaving alternative for these "no-option" patients.
You likely qualify if…
You likely don't qualify if…
If you qualify, you will receive the arterial-venous reversal flow procedure as part of your regular clinical care — no extra or experimental procedures. After your surgery, you will visit the clinic at 1 month, 6 months, 12 months, and 24 months so doctors can track how well the treatment is working, check your wound healing, and monitor your overall health. The study simply collects information about your medical care and outcomes over this 2-year period.
AI-generated summary from trial data · Jun 13, 2026 · Not medical advice
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