Testing a new injection treatment for advanced pancreatic cancer

Plain-English translation of NCT06278454 on ClinicalTrials.gov ↗ · Source last updated June 2026 · Translation generated June 2026 · How we translate trials

Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.

What is this trial?

This trial is testing a new medication called NRT6008 Injection, which uses special radioactive carbon microspheres, combined with standard chemotherapy drugs. The study wants to learn whether this treatment is safe and whether it can help people with advanced pancreatic cancer that cannot be surgically removed or has spread to lymph nodes. Researchers will track how well the treatment works and how patients respond to it.

Pancreatic cancer that cannot be surgically removed is very difficult to treat, and current options are limited. This trial exists to see if this new medication, when combined with chemotherapy, might offer another option for patients with this serious type of cancer and potentially help them live longer and with less pain.

Do you qualify?

You likely qualify if…

you are between 18 and 80 years old
you have been diagnosed with pancreatic cancer that cannot be surgically removed or has spread to lymph nodes only
you are in good enough general health to tolerate the treatment (ECOG score of 1 or less)
you have a pancreatic tumor that is visible on imaging scans and measures between 2.0 and 6.0 centimeters
your kidney, liver, bone marrow, and blood clotting function are adequate based on blood tests
you are willing to use effective birth control for 12 months after receiving the treatment (if of reproductive age)

You likely don't qualify if…

you are allergic to the medication NRT6008 or any of its ingredients
you have received previous chemotherapy, radiation, immunotherapy, or other anti-cancer treatments for pancreatic cancer
you have cancer that has spread to distant parts of your body beyond lymph nodes
you are pregnant, breastfeeding, or unwilling to use birth control
you have had another cancer diagnosed or treated within the past 5 years (except certain skin cancers or early-stage cancers)

What participation looks like

You would receive the NRT6008 injection combined with chemotherapy as your cancer treatment. The study will monitor your safety through regular blood tests, imaging scans, and check-ups to see how well the treatment is working and measure any side effects. Researchers will also track changes in tumor markers in your blood, improvements in cancer pain, and how the medication moves through your body.

AI-generated summary from trial data · Jun 15, 2026 · Not medical advice

Trial locations(6 sites)

China

Henan Cancer Hospital, Zhengzhou, Henan

Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu

Shanghai Changhai Hospital, Shanghai, Shanghai Municipality

Shanghai General Hospital, Shanghai, Shanghai Municipality

Chongqing University Cancer Hospital, Chongqing