Plain-English translation of NCT06283927 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Glioblastoma research guide →This international study is comparing two approaches for treating glioblastoma that has returned after initial treatment: surgical removal of the tumor versus medical treatments like chemotherapy, radiation, or other therapies. Researchers want to understand which approach is safer and helps patients live longer, by carefully measuring how well patients recover and function after treatment.
When glioblastoma comes back, doctors are not certain whether patients do better with surgery to remove it again or with medical treatments alone. This study aims to answer that important question so doctors can make better treatment recommendations in the future.
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If you enroll, you will be randomly assigned to either have surgery to remove the recurrent tumor or to receive medical treatment (such as chemotherapy, radiation, or supportive care). You will visit the study center at baseline, 6 weeks, 3 months, and 6 months after your treatment to have your neurological function, language, memory, and quality of life assessed through tests and questionnaires. The entire study, including follow-up visits, will last about 5 years.
AI-generated summary from trial data · Jun 28, 2026 · Not medical advice
United States
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Germany