Plain-English translation of NCT06296186 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This study is testing Prolonged Exposure Therapy (PE) delivered in two different formats for veterans who have both PTSD and substance use disorder. Some veterans will receive this one-on-one talk therapy several times per week (called 'massed' format), while others will receive it once per week. The research team wants to see which approach helps veterans recover better from PTSD, stick with treatment longer, and reduce substance use.
Many veterans struggle with both PTSD and substance use at the same time, which makes recovery harder and increases suicide risk. While the treatment is known to work, fewer veterans complete it and symptoms don't improve as much compared to those with only PTSD. This study explores whether receiving the treatment more frequently might help more veterans finish treatment and feel better.
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If you join this study, you will be assigned to receive Prolonged Exposure Therapy either in a massed format (multiple sessions per week) or in the standard weekly format. The therapy is one-on-one talk sessions with a trained therapist, delivered over twelve sessions total. You will also continue your regular substance use treatment programming. The study team will check in with you at different time points to measure how your PTSD symptoms, substance use, mood, and overall functioning are improving.
AI-generated summary from trial data · Jun 20, 2026 · Not medical advice
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