Plain-English translation of NCT06300463 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing whether and — two medications that help your immune system fight cancer — can work better when given before and after surgery to remove colorectal cancer tumors in your liver. Some participants will also receive additional treatments, like radiation or a third medication, to see if those combinations are even more effective. The goal is to understand how these medications change your tumor and immune system to help predict which patients will benefit most.
Colorectal cancer that has spread to the liver is serious, and surgery alone doesn't always prevent the cancer from coming back. Researchers believe that giving immune-boosting treatment before surgery — while the tumor is still in place — may help your body's immune cells recognize and fight the cancer better, improving your chances of long-term survival.
You likely qualify if…
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You will receive four infusions of the medications over several weeks — two before your scheduled liver surgery and two after. Each infusion visit is spaced about three weeks apart, and your surgery will happen roughly 4 to 6 weeks after your first treatment. After your last medication dose, you'll return to the clinic for follow-up visits at about 3 weeks and 3 months, then be monitored remotely for up to two years to see how you're doing.
AI-generated summary from trial data · Jun 3, 2026 · Not medical advice
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