Testing hormone therapy to help advanced prostate cancer respond to treatment

Plain-English translation of NCT06305598 on ClinicalTrials.gov ↗ · Source last updated May 2026 · Translation generated June 2026 · How we translate trials

Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.

What is this trial?

This study is testing a treatment approach called bipolar androgen therapy for men with advanced prostate cancer that has stopped responding to standard hormone-blocking drugs. The treatment involves giving testosterone injections in cycles while continuing your regular prostate cancer medication. The goal is to see whether this approach can make the cancer sensitive again to standard treatment and improve how well the medication works.

Many men with advanced prostate cancer eventually develop resistance to hormone-blocking therapy, meaning their cancer stops responding and continues to grow. This trial is exploring whether temporarily adding testosterone in a controlled way might reset the cancer's sensitivity and help standard treatments work better again.

Do you qualify?

You likely qualify if…

you are 18 years or older
you have been diagnosed with prostate cancer that has spread to other parts of your body
your cancer has continued to progress despite taking hormone-blocking medications and at least one additional prostate cancer drug
you have very low testosterone levels (kept low by castration or hormone therapy)
you have overall good health and organ function (including normal blood counts, liver, and kidney function)
you have measurable disease that can be tracked with imaging scans

You likely don't qualify if…

you have received chemotherapy or radiation therapy within the past 4 weeks
you have cancer that has spread to your brain
you have a history of blood clots or thromboembolic events
you have widespread disease in your lungs or liver (more than 5 separate sites)
you have active, untreated infections or a history of AIDS or hepatitis B or C

What participation looks like

You will receive testosterone injections once per month for 3 months, while continuing your regular prostate cancer medications. Throughout the study, you'll have CT scans, bone scans, and possibly MRI scans and biopsies to monitor how your cancer is responding. After the 3-month treatment period ends, you'll have follow-up visits at 1 month and then every 3 months for up to 2 years.

AI-generated summary from trial data · Jun 2, 2026 · Not medical advice

Testing hormone therapy to help advanced prostate cancer respond to treatment

What is this trial?

Do you qualify?

What participation looks like

Trial locations