Plain-English translation of NCT06308757 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
The KETONASH trial is testing whether a very low-calorie ketogenic diet (VLCKD) — a specialized eating plan with very few calories and no carbohydrates — can help heal fatty liver disease and reverse early liver scarring. You'll be compared to people following a standard Mediterranean-style low-calorie diet. Both groups will receive support from doctors, dietitians, nurses, and psychologists over 12 months.
Fatty liver disease with scarring is becoming more common and can lead to serious liver problems. Right now, weight loss is the main treatment, but doctors want to know if this special ketogenic diet works better than standard diets at reversing the damage.
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You'll be randomly assigned to either the ketogenic diet group or the standard diet group. Over 4 months, you'll follow your assigned eating plan with calories ranging from 600 to 1,500 per day, depending on which phase you're in. You'll have regular visits with a dietitian, doctor, nurse, and psychologist for check-ins, support, and adjustments. Then you'll spend 8 more months working to maintain your weight loss. At the end of 12 months, you'll have a second liver biopsy to see if the diet helped heal your liver damage.
AI-generated summary from trial data · Jun 9, 2026 · Not medical advice
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