Plain-English translation of NCT06308978 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.
This trial is testing a new treatment called , which uses specially engineered cells to help control the immune system in people with certain autoimmune diseases. The study will examine whether is safe and whether it can reduce the activity of B cells — immune cells that mistakenly attack the body in autoimmune conditions. Researchers will test the treatment in different doses and combinations to find the safest and most effective approach.
People with severe autoimmune diseases often don't respond well to standard treatments, leaving them with few options. This medication represents a new approach using cell therapy, which may work differently than traditional medicines and offer hope for patients whose disease hasn't improved with other treatments.
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Participants will receive either as a single dose or two doses over time, with some groups also receiving an additional medicine to help prepare the body. You may attend multiple study visits for medical exams, blood tests, and monitoring of how your disease responds to the treatment. The trial will track your safety and how well the medication works over several months.
AI-generated summary from trial data · Jun 11, 2026 · Not medical advice
United States