Plain-English translation of NCT06309550 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This research study is testing different diagnostic methods to help doctors more accurately identify a specific type of heart failure called heart failure with preserved ejection fraction (HFpEF). People with this condition often feel short of breath during physical activity, but it can be hard to diagnose. The study will compare several testing approaches—some involving exercise and heart monitoring—to find the best way to confirm this diagnosis.
Diagnosing this type of heart failure is challenging because symptoms overlap with many other conditions, especially in older adults with multiple health issues. Current diagnostic methods don't always work well, and researchers want to find better, standardized testing approaches that work for patients in Europe, not just the United States.
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Participants will complete various diagnostic tests to assess their heart function and breathing capacity. These may include non-invasive tests (like standard exercise stress tests) and possibly more advanced procedures that measure how the heart responds during exercise. The study will help researchers determine which combination of tests is most helpful for diagnosing this type of heart failure.
AI-generated summary from trial data · Jul 16, 2026 · Not medical advice
Italy
Enrollment target
~500 participants
Started
March 2023
Primary completion
March 2028
Last updated on clinicaltrials.gov in August 2025.
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Central contact
Sergio Caravita, MD, PhD
Istituto Auxologico Italiano
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