Can a breathing machine help control severe asthma?

This study is testing whether a CPAP machine—a device that gently pushes air through your nose to keep your airway open while you sleep—can help improve asthma control in people with severe asthma that hasn't responded well to standard treatments. Researchers have noticed that many people with severe asthma also have obstructive sleep apnea (a condition where breathing stops and starts during sleep), and treating the sleep apnea might help their asthma. This trial will compare people who use the CPAP machine against those who receive standard asthma care alone.

Small studies have shown that CPAP treatment may help people with mild-to-moderate asthma, but no one has studied whether it works for people with severe, uncontrolled asthma. This research aims to fill that gap and see if treating sleep apnea can be a new way to help people whose asthma isn't improving with current medications.