Plain-English translation of NCT06316232 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 4 — The treatment has already been approved. Researchers are tracking how it works in a large number of people over time.
This study is testing two ways to help people with advanced Parkinson's disease who experience freezing of gait—sudden, brief episodes where your feet feel stuck to the ground. You'll already have a deep brain stimulation device implanted in your brain. The trial will compare whether turning up the device's stimulation intensity or increasing your levodopa medication dose works better to reduce these freezing episodes.
Even with the best deep brain stimulation settings, some people with advanced Parkinson's still freeze while walking, which increases fall risk and limits independence. This trial exists to find out which approach—adjusting the device or adjusting the medication—is more effective at solving this specific walking problem.
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You will attend two morning study sessions scheduled close together. In one session, your brain stimulation device will be turned up to a higher setting; in the other session, your levodopa dose will be increased. During both visits, you'll walk through a series of timed exercises—like standing up and sitting down, turning in a circle, and walking while doing mental math—while the research team video records you and uses special sensors to measure how you move. The team will also ask you questions about your symptoms, balance, and thinking abilities.
AI-generated summary from trial data · Jul 1, 2026 · Not medical advice
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