Recruiting

Testing a New Way to Measure Airway Inflammation in Mild Allergic Asthma

Plain-English translation of NCT06317909 on ClinicalTrials.gov ↗ · Source last updated July 2026 · Translation generated July 2026 · How we translate trials

This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.

What is this trial?

Researchers are developing a new, non-invasive way to measure inflammation in the airways of people with mild allergic asthma. Instead of relying only on traditional breathing tests, this study combines advanced imaging (MRI scans) with controlled allergen challenges to better understand and track how your airways respond to allergens. This new measurement approach could help doctors monitor asthma more accurately in the future.

Current methods for measuring airway inflammation in asthma patients can be uncomfortable or limited in what they reveal. This trial aims to create a better, less invasive tool that could help doctors understand asthma inflammation more clearly and improve how they manage the condition.

Do you qualify?

You likely qualify if…

you are between 18 and 65 years old
you have had mild asthma for at least 12 months that is controlled with a rescue inhaler only
you have normal or near-normal lung function
you have a documented allergy to a common allergen like pollen, grass, or dust mites
you are a non-smoker or have quit smoking at least one year ago
if you are a woman of childbearing potential, you are using an effective form of contraception

You likely don't qualify if…

you are pregnant, nursing, or planning to become pregnant
you have moderate to severe asthma or other serious lung, heart, liver, or kidney diseases
you have abnormal heart rhythm or other significant health conditions that could affect the study results
you have smoked more than a pack of cigarettes in your lifetime
you have recently used oral corticosteroids or other asthma medications beyond a rescue inhaler

What participation looks like

You will visit the research center in Hannover about 10 times over 6 to 8 weeks. During your visits, you'll breathe in small amounts of your specific allergen while doctors measure how your airways respond, undergo two MRI scans to visualize your lungs, and have two bronchoscopy procedures (where a thin tube is passed down your airway to collect samples and deliver allergen directly). Before the main study, you'll also have a screening visit that includes breathing tests and allergy skin testing to confirm you're eligible.

AI-generated summary from trial data · Jul 10, 2026 · Not medical advice

Testing a New Way to Measure Airway Inflammation in Mild Allergic Asthma

What is this trial?

Do you qualify?

What participation looks like

Trial locations(1 site)