Plain-English translation of NCT06321458 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Obesity research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
The LightWAY trial is testing whether an intensive, two-year weight loss program works better than usual care for adults with severe and complex obesity. The intensive program includes meal replacements, behavioral support (counseling), and weight loss medication if needed. You'd be randomly assigned to either this intensive program or to standard care, which differs depending on whether you're in Denmark or the United Kingdom.
Many people with severe obesity struggle to lose weight with standard care alone. This trial is testing whether a more comprehensive approach—combining structured meals, counseling, and medication—can help people achieve better, lasting weight loss and improve their health.
If you're assigned to the intensive program, you'll participate for two years in three phases: an induction phase (12 weeks) using meal replacements and counseling, a transition phase (20 weeks) where you gradually reintroduce regular healthy foods and add physical activity, and a maintenance phase (72 weeks) focused on keeping the weight off with medication support as needed. If you're assigned to standard care, you'll receive usual treatment through your local health system—either your GP in Denmark or a specialist weight management clinic in the UK.
AI-generated summary from trial data · Aug 6, 2026 · Not medical advice
Denmark