Plain-English translation of NCT06322212 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.
People with type 2 diabetes often experience problems with memory, thinking, and mood — and they're at higher risk for dementia later in life. This trial is testing whether thiamine, a common B vitamin, can help repair and protect the blood vessels in the brain that are damaged by diabetes. Half of the participants will receive thiamine for 3 months, and half will receive a placebo (a pill with no active ingredient), so researchers can see if the vitamin actually works.
Studies suggest that people with type 2 diabetes often have low levels of thiamine, which may damage the protective barrier around blood vessels in the brain. Researchers want to know if raising thiamine levels could repair this damage and prevent memory loss, mood problems, and early dementia — especially since this treatment would be inexpensive and safe.
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You would visit UCLA for the study and receive either thiamine or a placebo pill to take daily for 3 months. During your visits, researchers would perform an MRI scan (a special imaging test) to look at blood vessel function in your brain, and they would give you tests to check your memory, thinking, and mood. The study will help researchers understand whether this simple, low-cost vitamin might protect the brains of people living with type 2 diabetes.
AI-generated summary from trial data · Jun 25, 2026 · Not medical advice
United States
Phase
Safety & dosing
Sponsor
University of California, Los Angeles
Collaborators
National Institute on Aging (NIA)
Enrollment target
~52 participants
Started
August 2024
Primary completion
December 2026
Age range
40 Years – 65 Years
Last updated on clinicaltrials.gov in March 2026.
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Central contact
Rajesh Kumar, PhD
University of California, Los Angeles
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