Plain-English translation of NCT06326996 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.
This trial is testing whether — a B vitamin — can help protect your memory and thinking skills after you have coronary artery bypass grafting (CABG), a common heart surgery. Half of participants will receive the medication, and half will receive a placebo (a dummy pill) to see if the vitamin makes a real difference. The researchers will check your thinking abilities and measure and other markers in your blood.
Some people experience memory and thinking problems after heart bypass surgery, which can affect quality of life. This study is exploring whether this affordable, safe medication could prevent those cognitive problems and help older heart patients recover better.
You likely qualify if…
You likely don't qualify if…
You will receive either or a placebo within 5 days before your bypass surgery. After surgery, you'll return about one month later for follow-up visits where researchers will test your memory and thinking skills and take blood samples to measure levels and inflammation markers. The entire study takes about one month from enrollment to final assessment.
AI-generated summary from trial data · Jun 2, 2026 · Not medical advice
United States
Phase
Safety & dosing
Sponsor
University of California, Los Angeles
Collaborators
National Institute on Aging (NIA)
Enrollment target
~52 participants
Started
October 2024
Primary completion
June 2026
Age range
60 Years – 80 Years
Last updated on clinicaltrials.gov in August 2025.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Rajesh Kumar, PhD
University of California, Los Angeles
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.