Plain-English translation of NCT06329544 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This research study is investigating how eating a diet high in fructose (a type of sugar) affects your gut bacteria and your body's ability to control blood sugar and weight. Researchers will ask you to follow two different controlled diets—one high in fructose and one high in glucose (regular sugar)—for 12 days each, with a 10-day break in between, while they monitor changes in your gut bacteria and metabolism. The goal is to understand whether fructose might be harmful to metabolic health by changing the composition and function of your gut microbiome.
Many Americans eat too much fructose from added sugars, and this has been linked to insulin resistance, type 2 diabetes, and obesity. However, scientists don't yet fully understand exactly how fructose causes these problems—specifically, whether it works by changing the bacteria in your gut. This study aims to answer that question so doctors can better advise patients about fructose intake.
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You will participate in two 12-day diet periods separated by a 10-day break. In one period, you'll eat a diet where 25% of your calories come from fructose; in the other period, you'll eat the same diet but with glucose instead. The study team will provide all your food to ensure careful control. Throughout the study, you'll provide stool samples, have blood drawn, and possibly undergo an MRI scan to measure liver fat. The whole study lasts about 5 weeks from start to finish.
AI-generated summary from trial data · Jun 1, 2026 · Not medical advice
United States