Plain-English translation of NCT06331169 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Breast Cancer research guide →Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.
This trial is testing a combination of two drugs: and , given together to people with advanced breast cancer. The cancer being studied has low HER2 expression, meaning it doesn't have high levels of a specific protein that some breast cancers have. Researchers want to see if combining these two medications is safe and whether it helps control the cancer.
Many breast cancers with low HER2 levels have limited treatment options after initial chemotherapy. This medication combination may offer a new way to treat this type of cancer by attacking it through different mechanisms at the same time.
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You would take the medication by mouth on a regular schedule and receive intravenous infusions of the second medication. The study will start with different dose levels to find the safest and most effective combination. You'll have regular visits for blood tests, imaging scans, and check-ups to monitor how well the treatment is working and watch for side effects. The study involves about 42 participants total across different dose groups.
AI-generated summary from trial data · Jun 18, 2026 · Not medical advice
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