Plain-English translation of NCT06333392 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
Colonoscopy is the gold standard for finding and removing precancerous growths in the colon before they become cancer. This trial compares two ways to perform colonoscopy: the standard method using air (carbon dioxide) and a newer method called Total Underwater Colonoscopy (TUC) that uses water instead. Researchers believe water may help doctors see flat, hard-to-detect lesions more clearly and completely remove them.
Some precancerous lesions—especially flat ones called serrated lesions—are easily missed or incompletely removed during standard colonoscopy, allowing cancer to develop later. Studies suggest that better detection of these lesions during screening could prevent more cases of colorectal cancer. This trial tests whether the water-based technique improves detection rates and ultimately reduces cancer risk.
You likely qualify if…
You likely don't qualify if…
If you join this trial, you will receive a colonoscopy screening exam at a participating center. You will be randomly assigned to either the standard air-based method or the new water-based technique. The procedure itself is similar to a routine colonoscopy—your doctor will insert a thin scope to examine your colon and remove any precancerous growths found. The main difference is how your colon is filled during the exam (water instead of air), which may help your doctor see and remove lesions more completely.
AI-generated summary from trial data · Aug 2, 2026 · Not medical advice
Norway
Sweden