Plain-English translation of NCT06335771 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Obesity research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
Researchers want to understand how a specific protein called TFEB in fat tissue cells affects your body's metabolism, especially in obesity and type 2 diabetes. The study will compare fat tissue from lean people to people with obesity or diabetes, and see how this tissue changes when people lose 10% of their body weight over about 6 months through diet.
Many people with obesity develop metabolic problems like fatty liver disease and type 2 diabetes, while others do not. Scientists don't fully understand why fat tissue in some people leads to these complications and in others doesn't. This research could eventually help doctors prevent or treat these conditions more effectively.
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You'll have a screening visit, then body composition imaging (DEXA and MRI scans) to measure your fat and muscle. You'll also have an overnight visit where researchers will take small tissue samples from your fat and muscle, and give you an intravenous infusion. If you're in one of the obesity or diabetes groups, you'll meet with the study team for dietary counseling to help you lose 10% of your body weight over about 6 months. Lean participants do not need to lose weight.
AI-generated summary from trial data · Jun 9, 2026 · Not medical advice
United States