Plain-English translation of NCT06335836 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This is a long-term research study that tracks older adults who have noticed some memory changes but don't yet have a diagnosis of dementia. Researchers want to understand how social isolation—having few close relationships or social connections—affects whether memory problems get worse over time. The study will also look at how brain networks change in people who are socially isolated compared to those with strong social connections.
Many older adults notice small memory changes that worry them, but we don't fully understand what causes some people to progress to serious memory loss while others stay stable. This research aims to find out whether staying socially connected might help protect the brain, and to develop a simple tool doctors can use to predict who is at higher risk of memory decline.
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If you join this study, you will complete visits over 3 to 5 years where researchers assess your social connections, loneliness, memory, and thinking abilities through questionnaires and tests. You will also have brain imaging scans (MRI) to look at how your brain networks are working. You may be placed in either a group with social isolation or a group without social isolation based on your answers about your social relationships, and researchers will follow both groups to see how their memory changes over time.
AI-generated summary from trial data · Jun 7, 2026 · Not medical advice
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