Plain-English translation of NCT06336382 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This research study is investigating whether psychosis that develops in older age—without memory problems—might be caused by early brain changes that lead to dementia. The researchers will use brain imaging scans, blood tests, and brain activity measurements to look for signs of neurodegeneration in older adults with psychotic symptoms and compare them to healthy older adults.
When psychosis appears suddenly in older age, it can sometimes signal the early stages of dementia like Alzheimer's disease. Understanding the brain changes behind this connection could help doctors identify and treat people at risk much earlier.
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You would come in for appointments where researchers will perform a brain imaging scan (PET scan), collect blood samples, and conduct simple tests to measure your brain activity and thinking skills. Your caregiver would be asked to provide information about your memory and daily functioning. The study involves a small group of 16 people, and you would be compared to healthy older adults to see if there are any differences in brain biomarkers.
AI-generated summary from trial data · Jun 11, 2026 · Not medical advice
United States
Sponsor
Jeremy Koppel
Collaborators
National Institute of Mental Health (NIMH)
Enrollment target
~16 participants
Started
February 2024
Primary completion
December 2026
Age range
65 Years – 85 Years
Last updated on clinicaltrials.gov in November 2026.
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Central contact
Nichole Hoehn, MS
Northwell Health
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