New Cancer Drugs Plus Special Diet and Vitamin C for Bowel Cancer

Plain-English translation of NCT06336902 on ClinicalTrials.gov ↗ · Source last updated March 2026 · Translation generated July 2026 · How we translate trials

Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.

What is this trial?

This trial is testing a combination approach for advanced colorectal cancer that has a KRAS mutation. You would receive and —two newer drugs designed to help your immune system fight cancer—along with a special fasting-mimicking diet and vitamin C infusions. The study wants to learn whether this combination is safe and whether it can help slow or shrink your cancer.

Many standard chemotherapy treatments stop working for colorectal cancers with KRAS mutations, and patients need new options. This trial is exploring whether this medication approach, paired with dietary changes, might be more effective for this hard-to-treat type of cancer.

Do you qualify?

You likely qualify if…

you have been diagnosed with advanced (stage IV) colorectal cancer that has spread to other parts of your body, with a confirmed KRAS gene mutation
your cancer has stopped responding to, or you cannot tolerate, standard chemotherapy drugs
you are 18 years or older and in good enough health to participate
you have a body mass index of at least 18.5
you do not currently have diabetes requiring medication
your blood counts and organ function (liver, kidneys) are adequate based on recent lab work

You likely don't qualify if…

you currently have diabetes and are taking diabetes medication
you take medications that cannot be safely stopped during fasting periods or that must be taken with food
you have received chemotherapy, immunotherapy, or radiation therapy within the past 3 weeks
you have a history of fainting or syncope
you have other active cancers requiring treatment

What participation looks like

You would visit the clinic every 6 weeks for up to 2 years. On certain days of each cycle, you would receive intravenous infusions of the two medications and vitamin C (each lasting about 30 minutes). Before each cycle, you would follow a special fasting-mimicking diet for 4 days, which involves eating very little. Throughout the study, you would have blood tests and imaging scans (CT or MRI) to check how your cancer is responding. After the main treatment period ends, you would return for follow-up visits at 30 days and then every 3 months.

AI-generated summary from trial data · Jul 3, 2026 · Not medical advice

New Cancer Drugs Plus Special Diet and Vitamin C for Bowel Cancer

What is this trial?

Do you qualify?

What participation looks like

Trial locations(3 sites)