Plain-English translation of NCT06337838 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.
This pilot trial is testing whether two medications — tranexamic acid and desmopressin — can safely help reduce bleeding in people with advanced kidney disease who are having surgery. Both medications have been used for many years, but doctors aren't sure how well they work specifically in patients with severe kidney problems. This study will gather information to help design a larger international trial in the future.
Large studies have mostly excluded people with advanced kidney disease, so we don't know if this medication works safely and effectively for them. People with severe kidney disease may have bleeding problems during surgery, and doctors need better evidence about which treatments work best for this group.
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If you enroll, you will receive one of the study medications through an IV about 20 minutes before your surgery begins. The study team will randomly assign you to receive either tranexamic acid alone, or tranexamic acid combined with desmopressin. The researchers will then monitor how much you bleed during and after surgery, track your recovery, and collect blood samples to understand how your body processes these medications.
AI-generated summary from trial data · Jun 15, 2026 · Not medical advice
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