Plain-English translation of NCT06339398 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Parkinson Disease research guide →This is a pilot study examining how exercise — specifically different volumes and intensities of aerobic training — affects people with Parkinson's disease. Researchers want to see whether low-intensity exercise done twice weekly or high-intensity exercise done five times weekly can improve motor symptoms, brain connectivity, mood, and other markers of health. The study will also measure changes in brain chemicals and brain activity using brain scans and EEG tests.
Parkinson's disease affects movement, thinking, and quality of life, and current treatment options are limited. This trial explores whether structured exercise programs at different intensities could be a meaningful, non-medication way to help manage symptoms and slow disease progression.
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You will be assigned to one of two exercise groups for 4 weeks. The 'extensive' group does 45-minute sessions of light aerobic exercise twice a week, while the 'intensive' group does 45-minute sessions of harder aerobic exercise five times a week. Throughout the study, you will have brain scans (MRI and EEG), blood tests to measure brain chemicals, walking tests, cognitive tests, and questionnaires about your symptoms and quality of life. The entire study lasts 4 weeks of active exercise plus additional testing visits.
AI-generated summary from trial data · Jul 1, 2026 · Not medical advice
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