Plain-English translation of NCT06341517 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing intensive transcranial magnetic stimulation (TMS)—a non-invasive procedure that uses magnetic pulses to stimulate specific brain regions—to treat negative symptoms of schizophrenia, such as reduced motivation, emotional flatness, and social withdrawal. Some participants will receive active TMS treatment to the cerebellum (the back part of the brain), while others will receive a placebo (sham) treatment that looks and feels similar but delivers no actual stimulation. The study will measure whether this treatment helps improve symptoms and everyday functioning.
Current treatments for schizophrenia don't work equally well for everyone, especially for negative symptoms that make it hard to feel motivated, connect with others, or enjoy activities. This trial explores whether intensive magnetic brain stimulation might fill that gap by targeting a specific brain region in a new way.
You likely qualify if…
You likely don't qualify if…
You will receive multiple TMS sessions per day over a period of treatment, with the exact schedule determined by the research team. Before starting, you'll have brain imaging (MRI scans) to map your individual brain circuitry so the treatment can be precisely targeted. During each session, a magnetic coil is placed against your scalp—you'll feel tapping sensations but the procedure is painless. The study will measure how the treatment affects your symptoms, mood, motivation, and thinking, along with brain imaging changes that show whether the treatment is working.
AI-generated summary from trial data · Jun 5, 2026 · Not medical advice
Switzerland
Sponsor
Indrit Begue
Collaborators
University of Geneva, Switzerland
Enrollment target
~70 participants
Started
April 2024
Primary completion
September 2026
Age range
18 Years – 65 Years
Last updated on clinicaltrials.gov in November 2024.
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