Plain-English translation of NCT06341595 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing whether —an immunotherapy drug—works better when combined with chemotherapy and radiation therapy for advanced stomach cancer patients whose cancer has spread to lymph nodes near the aorta (the body's main artery). The goal is to shrink the cancer enough so that surgery becomes possible. After treatment, eligible patients would have surgery to remove the tumor, followed by additional treatment as needed.
When stomach cancer spreads to lymph nodes near the aorta, it is usually considered too advanced for surgery alone. This trial is exploring whether combining three types of treatment—chemotherapy, radiation, and immunotherapy—can shrink the cancer enough to make surgery a safe and effective option, potentially improving survival for patients with this difficult-to-treat form of the disease.
You likely qualify if…
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You would receive the medication by IV infusion every 3 weeks, combined with chemotherapy tablets taken twice daily for 2 weeks at a time. Radiation therapy to the abdomen would begin in the second cycle and continue for about 5–6 weeks. After 4 cycles of this combined treatment, imaging scans would determine if surgery is now possible. If it is, you would have surgery within 4 weeks, and your doctor would then decide on any additional treatment needed. The study involves regular clinic visits, imaging scans, and blood tests to monitor your health and response to treatment.
AI-generated summary from trial data · Jun 13, 2026 · Not medical advice
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