Plain-English translation of NCT06347276 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This trial is studying what happens to the brain during a minimally invasive procedure to close a hole in the heart called a patent foramen ovale (PFO) or atrial septal defect (ASD). Researchers want to understand whether tiny blood clots form in the brain during or after this procedure, and whether clots that already exist inside the heart hole affect this risk. The study will use special brain imaging scans before and after surgery to look for these microscopic clots.
When doctors close a PFO or ASD with a catheter-based procedure, there is a known risk that tiny clots may travel to the brain during the operation. This trial aims to better understand how often this happens, how serious it is, and whether spotting clots already present in the heart hole before surgery can help predict and prevent brain complications.
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If you join this study, you will have a brain MRI scan before your scheduled heart closure procedure. During the procedure, doctors will use special imaging techniques to look inside your heart and check for any clots already present. After surgery, you will have follow-up brain MRI scans at 24 hours and one month to see if any tiny clots formed during the procedure. The study involves about three brain imaging visits over one month, in addition to your standard surgical care.
AI-generated summary from trial data · Jun 1, 2026 · Not medical advice
China
Sponsor
China National Center for Cardiovascular Diseases
Collaborators
Beijing Anzhen Hospital, The Affiliated Hospital of Xuzhou Medical University
Enrollment target
~800 participants
Started
January 2024
Primary completion
December 2026
Age range
18 Years – 65 Years
Last updated on clinicaltrials.gov in July 2025.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Chaowu Yan, PhD MD
Cardiovascular Institute and Fuwai Hospital
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.