Regenerating tooth pulp in mature teeth with two different techniques

This trial is testing two different ways to regenerate the living tissue (pulp) inside a mature adult tooth that has died and developed an infection at the root tip. One approach uses your body's natural blood clot to trigger healing, while the other uses platelet-rich fibrin (PRF)—a concentrate made from your own blood that contains extra growth factors to stimulate tissue regrowth. Researchers believe regenerating the pulp might work better than traditional root canal treatment because it restores the tooth's natural blood supply and immune defenses.

While standard root canal treatment removes the dead pulp and fills the space, teeth treated this way are more likely to be lost over time because they lose their natural nerve and blood supply, plus their immune protection. This trial exists to see whether regenerating the pulp—rather than removing it—could give teeth a better chance of long-term survival and health.