Plain-English translation of NCT06347978 on ClinicalTrials.gov โ ยท Source last updated ยท Translation generated ยท How we translate trials
This study doesn't follow the usual testing phases โ it may be an observational study or a different type of research.
This trial is testing a new approach to treating severe obsessive-compulsive disorder (OCD) using deep brain stimulation โ a procedure where surgeons implant tiny electrodes in specific areas of your brain to help reduce OCD symptoms. The study is designed for people whose OCD has not responded to medications, therapy, or other standard treatments. What makes this approach unique is that doctors first map your brain activity to find the exact locations and settings that work best for you, then implant a personalized device based on those findings.
Many people with severe OCD do not improve enough with medications and therapy alone, and they need other options. This trial exists to test whether a carefully customized brain stimulation device โ tailored to each person's unique brain activity patterns โ can safely and effectively reduce OCD symptoms in people who have run out of other treatment options.
The trial happens in three stages over many months. First, you will have surgery to place temporary electrodes in your brain so doctors can map which areas control your OCD symptoms and test different stimulation settings. Then, in a second surgery, doctors will permanently implant a brain stimulation device customized based on what they learned. Finally, you will be randomly assigned to either receive active stimulation or a sham (fake) treatment for 12 weeks, then switch to the other condition. Throughout the trial, you will have regular visits with psychiatrists or psychologists every three months to monitor your symptoms and the device's effects.
AI-generated summary from trial data ยท Jun 13, 2026 ยท Not medical advice
United States
Sponsor
Andrew Moses Lee, MD, PhD
Enrollment target
~10 participants
Started
May 2024
Primary completion
May 2028
Age range
22 Years โ 75 Years
Last updated on clinicaltrials.gov in June 2026.