Plain-English translation of NCT06349343 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.
This trial is testing a new treatment called for people with severe or treatment-resistant lupus. Researchers will collect some of your blood cells, train them in a lab to fight lupus-causing immune cells, and then put them back into your body. The goal is to see whether this living treatment can control lupus better than current medicines.
Many people with severe lupus don't get better even with strong medications like steroids and immunosuppressants, and long-term steroid use causes serious side effects. This trial exists because early research suggests this new cell-based treatment might work better and help patients reduce or stop taking steroids altogether.
You likely qualify if…
You likely don't qualify if…
You will have screening visits to confirm you qualify, then blood will be drawn and your cells sent to a lab to be processed. A small group of 3 participants will first receive the treatment without pre-chemotherapy to see if it works; depending on those results, you and other participants may receive the treatment with or without preparatory chemotherapy. You will then have follow-up visits and blood tests for up to 1 year to monitor how well the treatment works and check for side effects.
AI-generated summary from trial data · Jun 11, 2026 · Not medical advice
China
Phase
Safety & dosing
Sponsor
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Enrollment target
~20 participants
Started
February 2025
Primary completion
January 2026
This trial's estimated completion date has passed — the record may not be fully up to date.
Age range
18 Years – 70 Years
Last updated on clinicaltrials.gov in March 2025.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Qiubai Li, Professor
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.