Testing a new blood vessel medication for children with severe lung pressure

This trial is testing treprostinil sodium, a medication that helps relax blood vessels in the lungs, in children under 18 who have severe pulmonary arterial hypertension (a condition where blood pressure in the lung arteries becomes dangerously high). The researchers want to make sure this new version of the medication—made without preservatives—is safe and works well for children.

While this medication has been shown to work for children with this serious condition, the researchers removed a preservative from it to make it safer for ongoing use. This trial is needed to confirm that the new formulation without the preservative is still safe and effective.