Plain-English translation of NCT06351514 on ClinicalTrials.gov ↗ · Source last updated ·
Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.
This study is testing accelerated intermittent theta burst stimulation (iTBS) as a treatment for persistent negative symptoms in schizophrenia. Theta burst stimulation is a non-invasive brain stimulation technique that uses magnetic pulses to help improve brain function. Researchers want to see if this treatment can help people with schizophrenia who experience negative symptoms—like low motivation, reduced emotional expression, or difficulty with social interaction—that persist even after their acute psychotic symptoms have improved.
People with schizophrenia often struggle with negative symptoms that can be just as disabling as the psychotic symptoms, yet current medications and therapy approaches don't work well for these symptoms. This trial explores whether brain stimulation could offer a new and more effective treatment option for patients who haven't found relief with existing approaches.
If you qualify, you would receive five sessions of brain stimulation treatment, with multiple sessions each day over five working days. After the treatment period ends, you would have follow-up visits immediately after, then at one month, and again at three months to check how you're doing. During these visits, you'll complete some questionnaires and assessments to measure changes in your symptoms and overall functioning.
AI-generated summary from trial data · Jun 17, 2026 · Not medical advice
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