Plain-English translation of NCT06355583 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing whether -02—a capsule containing healthy gut bacteria—can help patients with blood cancers recover better after stem cell transplant. Your gut bacteria are damaged by chemotherapy and antibiotics, and researchers believe restoring them before transplant might reduce dangerous infections and other complications. You'll swallow 10 capsules about 2 weeks before your transplant and be compared to patients who receive placebo capsules.
Stem cell transplants are powerful treatments for blood cancers, but they can cause serious infections and complications because chemotherapy wipes out the healthy bacteria in your gut. Restoring these beneficial bacteria before transplant might help your body fight infections better and improve your chances of a smoother recovery.
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You'll attend routine study visits over several months, with the main treatment visit occurring about 2 weeks before your scheduled stem cell transplant. At that visit, you'll swallow 10 capsules containing either the healthy bacteria treatment or a placebo (inactive) capsule—you won't know which. Throughout your participation, you'll provide stool, urine, and blood samples at scheduled visits and complete questionnaires about how you're feeling. Your doctor will monitor you for infections, fever, hospital stays, and other health markers after your transplant.
AI-generated summary from trial data · Jun 3, 2026 · Not medical advice
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