Adding urea to dialysis fluid to prevent complications

This trial is testing whether urea added to dialysis fluid can help prevent a serious complication called dialysis disequilibrium syndrome. When patients need aggressive dialysis to quickly fix dangerous levels of potassium or acid in their blood, the rapid fluid shifts can sometimes cause severe headaches, nausea, confusion, or seizures. By carefully adding urea to the treatment fluid, researchers hope to smooth out these chemical changes and keep patients safer.

Patients who need fast, aggressive dialysis to treat life-threatening electrolyte imbalances are at high risk for severe and sometimes permanent complications from the rapid changes in their blood chemistry. This trial aims to find a simple way to make aggressive dialysis safer by reducing these dangerous symptoms.