Plain-English translation of NCT06366230 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 1/2 — A combined trial that checks safety and dosing while also starting to look at whether the treatment works.
This trial is testing whether urea added to dialysis fluid can help prevent a serious complication called dialysis disequilibrium syndrome. When patients need aggressive dialysis to quickly fix dangerous levels of potassium or acid in their blood, the rapid fluid shifts can sometimes cause severe headaches, nausea, confusion, or seizures. By carefully adding urea to the treatment fluid, researchers hope to smooth out these chemical changes and keep patients safer.
Patients who need fast, aggressive dialysis to treat life-threatening electrolyte imbalances are at high risk for severe and sometimes permanent complications from the rapid changes in their blood chemistry. This trial aims to find a simple way to make aggressive dialysis safer by reducing these dangerous symptoms.
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If you join this trial, you would receive dialysis treatment with urea added to your dialysis fluid in a carefully calculated amount based on your blood tests. Your vital signs, blood work, and symptoms would be closely watched throughout your treatment session to make sure the new approach is working and keeping you safe.
AI-generated summary from trial data · Jun 3, 2026 · Not medical advice
United States
Safety & dosing / Early efficacy
Sponsor
University of California, San Francisco
Enrollment target
~20 participants
Started
September 2025
Primary completion
June 2028
Age range
18 Years and older
Last updated on clinicaltrials.gov in February 2026.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Ramin Sam, MD
Zuckerberg San Francisco General- UCSF
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.