Recruiting

Breathing exercises and movement to help patients come off ventilators

Plain-English translation of NCT06368089 on ClinicalTrials.gov ↗ · Source last updated November 2024 · Translation generated August 2026 · How we translate trials

This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.

What is this trial?

This trial is testing whether two approaches—inspiratory muscle training (exercises to strengthen your breathing muscles) and early mobilization (gentle movement and positioning)—can help patients who have been on mechanical ventilators for more than 48 hours get off the breathing machine more successfully. The study will measure whether these interventions improve lung function, increase the time you can breathe on your own, and improve your chances of being weaned off the ventilator.

Patients who stay on ventilators for a long time often have weak breathing muscles and stiff lungs, which makes it very difficult to transition off the machine. Researchers want to know whether targeted breathing exercises and gentle movement earlier in the recovery process can strengthen your respiratory system and make weaning off the ventilator more likely to succeed.

Do you qualify?

You likely qualify if…

you have been on a mechanical ventilator for more than 48 hours and are ready to be weaned off or are currently undergoing a weaning trial
you are between 40 and 80 years old
your blood oxygen levels and heart rate are stable enough to participate safely
you are alert, able to follow directions, and can cooperate with the training exercises
you speak and understand Thai

You likely don't qualify if…

you have signs of clinical instability, such as very high or very low heart rate, rapid breathing, low oxygen levels, or dangerously high or low blood pressure
you have a condition that prevents you from sitting up or changing position, such as a recent spinal cord injury or head surgery
you have a history of coughing up blood, collapsed lung, or neuromuscular diseases that weaken muscles
you are on very high doses of heart-stimulating medications or have a heart rate above 140 beats per minute
you have very low hemoglobin levels (severe anemia) or a difficult airway that makes breathing support complicated

What participation looks like

You will be assigned to one of two groups: one group will receive inspiratory muscle training (breathing exercises designed to strengthen the muscles you use to breathe in), and the other group will participate in early mobilization (gentle movement and positioning exercises). Throughout your time on the ventilator and during the weaning process, the research team will monitor your lung function, measure how long you can breathe on your own during trials, and track your progress toward successfully coming off the ventilator.

AI-generated summary from trial data · Aug 26, 2026 · Not medical advice

Trial locations(1 site)

Thailand

Medical Respiratory Care Unit (MRCU), Prince of Songklanakarind Hospital, Songkhla