Plain-English translation of NCT06370988 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This study is testing a treatment called intermittent theta-burst stimulation (iTBS) — a non-invasive brain stimulation technique — to see if it can reduce depression in people with bipolar disorder who have not responded well to standard medications. Some participants will receive active stimulation, while others will receive a sham (placebo) stimulation that feels and looks identical. The study will measure how much your depression improves over 30 days of treatment and for 6 weeks afterward.
Many people with bipolar disorder struggle with depression that doesn't improve with standard antidepressants and mood-stabilizing medications. This trial exists to explore whether brain stimulation could offer hope to those who haven't found relief through medication alone.
You likely qualify if…
You likely don't qualify if…
You will come to the clinic once per day for 30 consecutive days to receive a brief brain stimulation session (about 3 minutes and 9 seconds each). During each visit, a magnetic coil will be placed on your scalp — you'll feel tapping and hear clicking sounds, but the procedure is painless. Every five sessions and after treatment ends, you'll complete simple questionnaires about your mood. You'll also have a follow-up visit 1 week after treatment ends and another at 6 weeks to check how you're doing.
AI-generated summary from trial data · Jun 2, 2026 · Not medical advice
Canada