Comparing weight loss surgery versus diet for people with obesity and liver disease

This trial is comparing two approaches for people with severe obesity who also have liver disease: either following a structured dietary program with professional support, or undergoing weight loss surgery (such as gastric bypass or sleeve gastrectomy). Researchers will track changes in participants' blood markers, immune system, and special molecules called microRNAs to understand how each approach affects their health and whether surgery or diet works better for their particular situation.

Many people with severe obesity don't get relief from diet and exercise alone, and surgery can help—but doctors don't always know which patients will benefit most from surgery versus continuing with nutrition and lifestyle support. This study aims to understand the biological changes that happen with each approach, especially in people who have both obesity and liver disease, so doctors can make better treatment choices.