Plain-English translation of NCT06373016 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
Researchers want to understand how different fuel sources — glucose (sugar) and ketones (an alternative energy source) — affect how your brain works when you have bipolar disorder. This study uses brain imaging to see what happens to your brain's activity and chemistry when you consume glucose versus ketones. The goal is to find out whether one energy source might help stabilize mood and brain function better than the other.
Bipolar disorder involves imbalances in brain chemistry and energy metabolism. Early research suggests that ketones — which your body produces during fasting or on certain diets — might help regulate the brain circuits involved in mood, risk assessment, and reward. This study explores whether this alternative energy source could offer a new way to support brain stability in people with bipolar disorder.
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You will visit the hospital twice for scanning sessions, each lasting a few hours. On each visit, you'll fast for 8 hours, then have blood drawn to check your baseline metabolism. During the scan, you'll have brain imaging while doing simple cognitive tasks (like playing games), then you'll drink either glucose or ketones. Researchers will repeat the brain imaging after your drink, and check your blood sugar and ketone levels three times using finger-prick tests. The two visits will test both glucose and ketones so researchers can compare how each affects your brain.
AI-generated summary from trial data · Jun 2, 2026 · Not medical advice
United States