Plain-English translation of NCT06373718 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing whether a well-established sleep therapy called Cognitive Behavioral Therapy for Insomnia (CBT-I) can help reduce depression and anxiety by repairing how your brain regulates emotions. Researchers believe that poor sleep damages the brain circuits that control feelings, and that fixing your sleep might repair these circuits and improve your mood. This study will compare people who receive the sleep therapy right away to those who wait several months, to see if the treatment truly helps.
Insomnia and depression often go hand-in-hand, and people with both conditions have a higher risk of suicidal thoughts. While this sleep therapy is proven to help insomnia, doctors don't yet know whether it also fixes the specific brain circuits that handle emotions, or whether repairing those circuits is what actually makes depression and anxiety better.
You likely qualify if…
You likely don't qualify if…
If you are randomly chosen for the immediate treatment group, you would receive 6 sessions of the sleep therapy over 8 weeks, meeting with a therapist to learn techniques to improve your sleep. If you are in the comparison group, you would receive basic sleep education for a few months while researchers monitor your sleep and mood, then get offered the full sleep therapy about 7 months later. Throughout the study, you would complete assessments of your sleep, mood, and brain activity using brain imaging scans to help researchers understand how the treatment works.
AI-generated summary from trial data · Jun 2, 2026 · Not medical advice
United States
Sponsor
Stanford University
Collaborators
National Institute of Mental Health (NIMH)
Enrollment target
~120 participants
Started
August 2024
Primary completion
June 2027
Age range
18 Years – 65 Years
Last updated on clinicaltrials.gov in April 2026.
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Central contact
Kaela Mandler
Stanford University
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