Plain-English translation of NCT06377111 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.
This trial is testing whether calcium pantothenate (a form of vitamin B5) can help boost the effectiveness of your melanoma immunotherapy. You would take a daily oral supplement alongside your standard immunotherapy drugs ( and ). The researchers will monitor your blood, stool samples, and immune system to understand whether this medication helps your body fight the cancer better and may reduce common side effects from immunotherapy.
Immunotherapy works well for some melanoma patients, but not all, and it can cause side effects like gut inflammation. This study explores whether this medication might enhance how well immunotherapy works and possibly protect your digestive system from these side effects.
You would take four 500 mg capsules of the supplement by mouth each morning before eating. You'll start with a 3–7 day run-in period before beginning your standard immunotherapy, then continue the medication daily alongside your immunotherapy for up to one year. You'll have clinic visits roughly every 8–12 weeks for imaging scans, blood tests, and stool sample collection to monitor your cancer and immune response. The study will end when your cancer progresses, you experience unacceptable side effects, you begin a new cancer treatment, or after one year—whichever comes first.
AI-generated summary from trial data · Jun 11, 2026 · Not medical advice
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