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Comparing an Ivy Extract Syrup to a Standard Mucus-Clearing Medicine for COPD

Plain-English translation of NCT06377410 on ClinicalTrials.gov ↗ · Source last updated November 2025 · Translation generated June 2026 · How we translate trials

This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.

What is this trial?

This study is testing whether , a medicine made from ivy extract, works as well as NAC (a standard mucus-thinning medication) for treating symptoms of COPD. You would be randomly assigned to take one of these two medications for one month. The researchers want to see how well each medicine helps with coughing, breathing, and quality of life.

COPD patients often struggle with excess mucus and cough that affect their daily activities. Doctors currently use NAC to help clear mucus from the lungs, but researchers want to know if this medication could work better or if a natural alternative like ivy extract might be just as good with fewer side effects.

Do you qualify?

You likely qualify if…

you are 40 years of age or older
you have been diagnosed with stable COPD (your condition is not currently getting worse)
you can perform a breathing test (spirometry) to measure how well your lungs work
your lung test results show airway obstruction typical of COPD

You likely don't qualify if…

you have other chronic lung diseases such as asthma, asthma-COPD overlap, interstitial lung disease, bronchiectasis, or lung cancer
you are allergic or sensitive to NAC or ivy extract
you are pregnant or breastfeeding
you are already taking other mucus-thinning medications regularly
you have severe heart or lung problems that make it unsafe to perform breathing tests

What participation looks like

You would visit the clinic to have breathing tests and answer questions about your cough and quality of life. Then you would take either the ivy extract syrup or NAC twice a day for one month. You would return for a check-in visit on day 15 to make sure the medication is working well and you are not having side effects. On day 30, you would have the same tests and questionnaires repeated to see how much your symptoms improved.

AI-generated summary from trial data · Jun 5, 2026 · Not medical advice

Trial locations(2 sites)

Malaysia

National University of Malaysia, Faculty of Medicine, Cheras, Kuala Lumpur

National University of Malaysia, Cheras, Kuala Lumpur

Key details

Sponsor

National University of Malaysia

Enrollment target

~100 participants

Started

May 2024

Primary completion

November 2026

Age range

40 Years and older

Last updated on clinicaltrials.gov in November 2025.

Contact the research team directly

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Central contact

Mohamed Faisal Abdul Hamid, MBBS (IIUM)

National University of Malaysia

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View full record on ClinicalTrials.gov