Plain-English translation of NCT06379087 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing a new combination approach for people with stage II or IIIA non-small cell lung cancer. You would receive radiation therapy over three days, followed by two medications called tislelizumab and anlotinib given together before surgery, then continue taking these medications for one year after surgery. The goal is to see if this combination approach helps improve survival and reduces the cancer's ability to return.
For people with earlier-stage lung cancer, current treatments don't always prevent cancer from returning. This trial is exploring whether combining radiation therapy with these two medications before and after surgery might work better than standard approaches alone.
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Over about one year, you would receive radiation therapy on three consecutive days early in the study, then start taking the two medications by mouth and injection for two cycles (six weeks total) before surgery. After surgery, you would continue taking the same medications for one year, with check-in visits every three weeks. Throughout this time, your doctors would monitor you for side effects and use scans and tests to see how well the treatment is working.
AI-generated summary from trial data · Jul 21, 2026 · Not medical advice
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